Toronto coach Nick Nurse challenged the call on Siakam's sixth foul with 1:41 to play, but a review confirmed it and George Hill pushed the lead to six with two free throws.
Antetokounmpo would end with a season-best 36 points with 15 boards, eight assists and four swats while going 14-for-20 from the field.
For more on this battle at the Fiserv Forum, we have you covered with takeaways below.
As Giannis Antetokounmpo popped up from his customary pregame nap Saturday, the NBA's defending champion Toronto Raptors were on his mind. Norman Powell contributed 19 points and two steals off the bench.
The lead reached 22 points early in the second quarter when Lopez made a 3-pointer. Their offence was stagnant, they were forcing tough shots and they had five turnovers to just one assist. Going into Milwaukee to face the Bucks, the Toronto Raptors found themselves down 26 less than 18 minutes after the opening tip.
According to NBA.com, the Bucks have outscored opponents by 17.3 points per 100 possessions in the first half of games, the best net rating in the league. In the end, it finished as a 10-point Milwaukee victory. The Raptors began to chip away at their lead, cutting the deficit to 16 points at the half.
With the Bucks improving to 4-2 on the season, last year's playoff defeat is now a distant memory, but Milwaukee needs to address its problem with maintaining big leads. Their 32-point win against the Magic was the only time their big lead hasn't been in serious danger. (Kyle) Lowry is still playing unbelievable.
Lowry was the sole bright spot in Toronto's awful first quarter, scoring eight points on 2-for-4 shooting from beyond the arc with the team's only assist. Lowry only took two of the Raptors 23 shot attempts in the fourth quarter, hitting one.
He also scored 21 in the half-court en route to becoming the first player in Bucks history to record at least 35 points, 15 rebounds, 8 assists and 4 blocks in a single game since blocks were first recorded in the 1973-74 season, per ESPN Stats & Information research. This adds to Lowry's fantastic start to the season, averaging 24.0 points, 6.8 assists and 5.0 rebounds per game. However, it's one thing to say that there will be considerable interest in Antetokounmpo, it's another to suggest that Toronto would be near the top of the list in potential landing spots. However, midway through the quarter, the Raptors jumped into a 3-2 zone.
But there was more to it than just a huge stat line. Siakam ended up fouling out of the contest in the fourth quarter and a lot of the credit can go to Antetokounmpo attacking him time-and-time again.
"Forty points, you give up 40", Budenholzer said.
"We played bad. We couldn't make a shot".