The City boss will be hoping his side can pick up a valuable three points on Sunday as they go in search of a third consecutive league title.
Man City have been dealt a major blow with the news that Ederson is set to miss out after suffering a thigh injury against Atalanta so Claudio Bravo is expected to deputise between the sticks.
All logic suggests, given Liverpool's form over the past 18 months, that victory and that increasing gap would simply not give Manchester City - or anyone else - enough wriggle room to claw it back. "We'll fight until the very end", the 31-year-old told the club website. It was quite similar to the Champions League game.
Alisson will continue in goal for Liverpool against City, and will start his fifth league game of the season.
City's excellence under Guardiola has nearly been taken for granted in some quarters.
Kompany has now outlined what made the title victory stand out in City's domestic treble winning season. It is remarkable that this achievement seems to have been downplayed given its scale. Pep Guardiola's side will not sit back, but they will suffocate the service into the front three of Liverpool and try to nullify the full-backs. That could be an ominous omen for Liverpool heading into the crunch contest at Anfield.
Sadio Mane is showing up in the big moments week after week, and it's nearly a usual feat for him to score or get a penalty in the 90th minute of the match to earn a win for Liverpool.
Liverpool have been a little unsteady in recent weeks.
As for Anfield itself, City will need to turn the tide of history on Sunday.
Bernardo Silva pulled a goal back for City in the 78th minute, drilling home a low cross from Angelino and the visitors enjoyed some late pressure but Liverpool held firm. In all competitions, they have played 18 and lost 12. It was a rotten game of football last time, but this is what tension does to the best of teams - City can not afford to lose it. Pep Guardiola's side eventually won the league by one point and their performances against the Reds proved pivotal.
It is, on this occasion, a game unlikely to be characterised by caution.
The Premier League game in Liverpool is available in most countries through the rights holders' online platform, if they have one. It is a rivalry with a serious edge on and off the pitch - and the evidence has been there again in the build-up to Sunday's game.